GeneSeqDx oncology testing uses Next Generation Sequencing (NGS) panels to analyze genes that are associated with hereditary and somatic cancers.
1. Hereditary Cancer Screening
BRCA
Comprehensive Next Generation Sequencing panel of BRCA 1 and BRCA 2 for variants, deletions and duplications. Germline BRCA1 and BRCA2 mutations are associated in 25-50% of hereditary breast cancer cases.
BRCA 1, BRCA 2
Breast
Complete Next Generation Sequencing panel of genes associated with increased risk of Breast Cancer including BRC1 and BRCA2 .
BRCA1, BRCA2, CDH1, CHEK2, MET, -PALB2, PTEN, STK11, TP53
Ovarian
Next Generation Sequencing panel that analyzed genes associated with increased risk for breast, ovarian, and/or uterine cancers.
BRCA1, BRCA2, EPCAM, MLH1, MSH2, MSH6, PMS1, PMS2, STK11, TP53
Uterine
Full Next Generation Sequencing panel of genes associated with increased risk uterine cancers
EPCAM, MLH1, MSH2, MSH6, PMS1, PMS2, PTEN, STK11, TP53
Gynecological
Comprehensive Next Generation Sequencing panel of genes associated with ovarian, endometrial, and other gynecological cancers
BRCA1, BRCA2, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, PTEN, STK11, TP53
Colorectal
Next generation sequencing panel that analyzes genes associated with increased risk colorectal cancer.
APC, BMPR1A, CDH1, CHEK2, EPCAM, MLH1, MSH2, MSH6, MUTYH, PMS1, PMS2, PTEN, SMAD4, STK11, TP53
Pancreatic
Comprehensive Next Generation Sequencing panel of genes associated with increased risk pancreatic cancers
APC, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, STK11, TP53
Gastric
Comprehensive Next Generation Sequencing panel of genes associated with gastric, colorectal, and other gastrointestinal cancers
APC, BMPR1A, CDH1, EPCAM, MET,MLH1, MSH2, MSH6, SMAD4, STK11, TP53
Prostate
Next Generation Sequencing panel of genes associated with increased risk prostate cancer.
BRCA1, BRCA2, TP53
Thyroid
Complete Next Generation Sequencing panel of genes associated with thyroid cancer.
APC, MEN1, PTEN, RET, TP53
Neuroendocrine
Next Generation Sequencing panel of genes associated with neuroendocrine tumors
RET, SDHA, SDHB, SDHC, VHL
Lynch Syndrome
Next Generation Sequencing analysis of gene associated with Lynch Syndrome
EPCAM, MLH1, MSH2, MSH6, PMS2
Melaloma
Next Generation Sequencing analysis of gene associated with Melaloma, BRCA2, CDKN2A, TP53
Comprehensive
Complete Next Generation Sequencing panel of genes associated with cancer risks.
2. Somatic Cancer Diagnosis
Breast
Next Generation Sequencing panel that analyzed genes associated with breast cancer diagnosis.
ATM, CDH1, CSF1R, ERBB2, ERBB4, PTEN, TP53, FBXW7, FGFR1, FGFR2, MLH1, PIK3CA, STK11
Ovarian
Next Generation Sequencing panel that analyzed genes associated with ovarian cancer diagnosis.
ALK, BRAF, CTNNB1, ERBB2, FBXW7, FGFR1, KRAS, MLH1, PIK3CA, STK11
Uterine
Next Generation Sequencing panel that analyzed genes associated with uterine cancer diagnosis
FGFR2, MLH1, PTEN, SRC
Colorectal
Next generation sequencing panel that analyzed genes associated with colorectal cancer diagnosis.
ALK, APC, BRAF, CDH1, CTNNB1, ERBB4, FLT3, IDH1, KRAS, MLH1, MPL, PIK3CA, PTEN, SNAD4, STK11
Pancreatic
Next Generation Sequencing panel that analyzed genes associated with pancreatic cancer diagnosis.
ATM, CDKN2A, KRAS
Gastric
Next Generation Sequencing panel that analyzed genes associated with gastric cancer diagnosis.
CDH1, ERBB2, ERBB4, HNF1A, JAK3, KIT, MLH1, PDGFRA, SMAD4, SMARCB1, STK11, TP53, VHL
Thyroid
Next Generation Sequencing panel that analyzed genes associated with thyroid cancer diagnosis.
BRAF, GNAS, HRAS, RET
Skin
Complete Next Generation Sequencing panel that analyzed genes associated with skin cancer diagnosis.
BRAF, CDKN2A, CTNNB1, EGFR, GNA11, GNAQ, HNF1A, JAK3, KDR, MPL, NRAS, PTEN, RB1, SMO
SRC, TP53
Brain
Next Generation Sequencing panel that analyzed genes associated with brain cancer diagnosis.
ALK, APC, CTNNB1, HRAS, IDH1, MLH1, PTEN, SMARCB1, TP53, VHL
Endocrine
Next Generation Sequencing analysis panel that analyzed gene associated with endocrine cancer diagnosis.
GNAS, MLH1, PIK3CA, PTEN, RET, VHL
Lung
Next Generation Sequencing panel that analyzed gene associated with lung cancer diagnosis.
AKT1, ALK, EGFR, ERBB2, ERBB4, FBXW7, KDR, KIT, KRAS, MET, MPL, PIK3CA, RET
Hematology
Next Generation Sequencing panel that analyzed gene associated with hematology cancer diagnosis.
ABL1, FGFR3, FLT3, HRAS, IDH1, JAK2, KRAS, MLH1, MPL, NOTCH1, NPM1, PDGFRA, PTPN11, RET, TP53
Head and Neck
Next Generation Sequencing panel that analyzed gene associated with head and neck cancer diagnosis.
CDKN2A, FBXW7, HRAS, MET, NOTCH1
Renal
Next Generation Sequencing panel that analyzed gene associated with renal cancer diagnosis.
GNAS, HRAS, MET, CMARCB1, VHL
Comprehensive
Complete Next Generation Sequencing panel of genes associated with cancer risks.
ABL1, AKT1, ALK, APC, ATM, BRAF, CDH1, CDKN2A, CSF1R, CTNNB1, EGFR, ERBB2, ERBB4, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, GNA11, GNAQ, GNAS, HNF1A, HRAS, IDH1, GAK2, GAK3, KDR, KIT, KRAS, MET, MLH1, MPL, NOTCH1, NPM1, NRAS, PDGFRA, PIK3CA, PTEN, PTPN11, RB1, RET, SNAD4, SMARCB1, SNO, SRC, STK11, TP53, VHL
Custom
Next generation sequencing panel that analyzes genes of your choice associated with breast, colon, ovarian, pancreatic, kidney, uterine, and many other cancers.